Anhedonia refers to the reduced ability to experience pleasure, and has been studied in different neuropsychi- atric disorders. Anhedonia is nevertheless considered as a core feature of major depressive disorder, according to DSM-IV criteria for major depression and the definition of melancholic subtype, and regarding its capacity to predict antidepressant response. Behavioral, electrophysiological, hemodynamic, and interview-based measures and self- reports have been used to assess anhedonia, but the most interesting findings concern neuropharmacological and neuroanatomical studies. The analyses of anhedonic non- clinical subjects, nonanhedonic depressed patients, and depressed patients with various levels of anhedonia seem to favor the hypothesis that the severity of anhedonia is associated with a deficit of activity of the ventral striatum (including the nucleus accumbens) and an excess of activ- ity of ventral region of the prefrontal cortex (including the ventromedial prefrontal cortex and the orbitofrontal cor- tex), with a pivotal, but not exclusive, role of dopamine. © 2008, LLS SAS Dialogues Clin Neurosci. 2008;10:291-299.

via The Core of Depression-27.

I want my Dopamine-and I want it NOW!
If you can read and understand this:
“The nucleus accumbens receives projections from midbrain regions (such as the ventral tegmental area), from regions involved in emo- tion (such as the amygdala, orbitofrontal cortex, and medial prefrontal cortex), from motor regions (such as the dorsal caudate and globus pallidus), and from regions involved in memory (such as the hippocampus).” Just click the link and enjoy the rest of this lengthy, educational and facinatimng article. Diane